Thrombolytic Therapy A New Strategy for the Treatment of Acute Myocardial Infarction

WITH the introduction of coronary-care units in the 1960s and the ability to prevent and treat lethal arrhythmias, the mortality from acute myocardial infarction was reduced for the first time. Failure of the cardiac pump subsequently emerged as the principal cause of in-hospital death in patients w...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 311; no. 11; pp. 710 - 717
Main Authors Laffel, Glenn L, Braunwald, Eugene
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 13.09.1984
Subjects
Animals
Cardiovascular disease
Collateral Circulation
Coronary Artery Bypass
Coronary Circulation - drug effects
Coronary Disease - drug therapy
Coronary Vessels
Electrocardiography
Fibrinolysis
Fibrinolytic Agents - therapeutic use
Heart - drug effects
Heart - physiopathology
Heart attacks
Humans
Hypotheses
Injections - methods
Ischemia
Laboratory animals
Mortality
Myocardial Contraction
Myocardial Infarction - drug therapy
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
Streptokinase - administration & dosage
Streptokinase - therapeutic use
Supply & demand
Thrombolysis
Thrombosis
Time Factors
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Summary:WITH the introduction of coronary-care units in the 1960s and the ability to prevent and treat lethal arrhythmias, the mortality from acute myocardial infarction was reduced for the first time. Failure of the cardiac pump subsequently emerged as the principal cause of in-hospital death in patients with myocardial infarction. Unfortunately, the present treatment of pump failure with positive inotropic and vasoactive agents and with circulatory-assist devices has not improved the prognosis any further. In the late 1960s, it was thought that mortality from pump failure might be reduced by attempts to limit the quantity of jeopardized myocardium destined to undergo . . .
Bibliography:ObjectType-Article-2
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198409133111105