Phosphinic peptide inhibitors as tools in the study of the function of zinc metallopeptidases

The development of the combinatorial chemistry of phosphinic peptides has led to the discovery of both highly potent and selective inhibitors of various zinc metalloproteinases. Several properties of these compounds are reviewed, supporting the view that this class of inhibitors should represent use...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 28; no. 4; p. 455
Main Authors Dive, V, Lucet-Levannier, K, Georgiadis, D, Cotton, J, Vassiliou, S, Cuniasse, P, Yiotakis, A
Format Journal Article
LanguageEnglish
Published England 01.08.2000
Subjects
Aminopeptidases - chemistry
Aminopeptidases - metabolism
Combinatorial Chemistry Techniques
Metalloendopeptidases - metabolism
Models, Chemical
Models, Molecular
Peptide Library
Peptides - chemistry
Peptides - metabolism
Zinc - metabolism
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Summary:The development of the combinatorial chemistry of phosphinic peptides has led to the discovery of both highly potent and selective inhibitors of various zinc metalloproteinases. Several properties of these compounds are reviewed, supporting the view that this class of inhibitors should represent useful tools for probing several aspects of the function of this broad family of proteases in vivo.
ISSN:0300-5127
DOI:10.1042/0300-5127:0280455