Pretzelanes, [1]rotaxanes and molecular figures-of-eight - crossing the bridge from fundamentals to functional applications

There are myriad [2]catenanes and [2]rotaxanes that consist of two interlocked molecular components. On occasion, supramolecular chemists prepare interlocked molecules where there are covalent linkages between the interlocked molecular components. In this review, progress on pretzelanes ([1]catenane...

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Published inOrganic & biomolecular chemistry Vol. 23; no. 12; pp. 2756 - 2774
Main Authors Spicer, Rebecca L, Evans, Nicholas H
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 19.03.2025
Subjects
Rotaxanes
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Summary:There are myriad [2]catenanes and [2]rotaxanes that consist of two interlocked molecular components. On occasion, supramolecular chemists prepare interlocked molecules where there are covalent linkages between the interlocked molecular components. In this review, progress on pretzelanes ([1]catenanes), [1]rotaxanes and molecular figures-of-eight is surveyed. Particular attention is paid to the application of such molecules, especially where the interlocked structure and/or the covalent linkage(s) play a key functional role. A survey of pretzelanes, [1]rotaxanes and molecular figures-of-eight - examples of mechanically interlocked molecules possessing covalent linkage(s) between their interlocked components.
Bibliography:Bec Spicer graduated with a First Class Masters in Chemistry from the University of St Andrews in 2015. She then moved to Prof Paul Lusby's laboratory at the University of Edinburgh, completing a PhD thesis on coordination capsule catalyzed organic transformations. In 2020, Bec moved to Lancaster University, where she has undertaken postdoctoral research on [1]rotaxanes inspired by lasso peptides. During 2024, she commenced a Leverhulme Trust Early Career Fellowship at Lancaster University.
Nick Evans graduated from Wadham College, University of Oxford with a First Class Masters in Chemistry (2006) and DPhil in Inorganic Chemistry (2011), having worked on anion sensing rotaxanes and catenanes under the supervision of Prof Paul Beer. Nick then undertook postdoctoral research on lanthanide complexes with Prof David Parker at Durham University. In 2013, Nick commenced his independent academic career at Lancaster University, where he is currently Senior Lecturer and Head of Department. His research interests are in functional supramolecular chemistry, seeking to exploit mechanically interlocked molecules in useful applications.
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ISSN:1477-0520
1477-0539
DOI:10.1039/d5ob00031a