Nanotherapeutics: Engineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation (Adv. Sci. 15/2019)

In article number 1900605, Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for inflammation therapy. These therapies utilize a functional nanoparticle core decorated with engineered cell‐membrane vesicles. Nanoparticle co...

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Published inAdvanced science Vol. 6; no. 15
Main Authors Yan, Huize, Shao, Dan, Lao, Yeh‐Hsing, Li, Mingqiang, Hu, Hanze, Leong, Kam W.
Format Journal Article
LanguageEnglish
Published Hoboken John Wiley and Sons Inc 07.08.2019
Subjects
biomimetic nanomedicine
cell membrane engineering
Cover Picture
inflammation
inflammatory microenvironment
targeted drug delivery
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Abstract In article number 1900605, Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for inflammation therapy. These therapies utilize a functional nanoparticle core decorated with engineered cell‐membrane vesicles. Nanoparticle cores that are organic (polymer), inorganic (silica and metal nanoparticle), or hybrid (such as metal–organic frameworks) in nature are all applicable. With judicious choice of cell membranes, these nanotherapeutics can achieve targeted delivery to the inflammatory environment for enhanced therapeutic efficacy.
AbstractList In article number 1900605 , Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for inflammation therapy. These therapies utilize a functional nanoparticle core decorated with engineered cell‐membrane vesicles. Nanoparticle cores that are organic (polymer), inorganic (silica and metal nanoparticle), or hybrid (such as metal–organic frameworks) in nature are all applicable. With judicious choice of cell membranes, these nanotherapeutics can achieve targeted delivery to the inflammatory environment for enhanced therapeutic efficacy.
In article number 1900605, Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for inflammation therapy. These therapies utilize a functional nanoparticle core decorated with engineered cell‐membrane vesicles. Nanoparticle cores that are organic (polymer), inorganic (silica and metal nanoparticle), or hybrid (such as metal–organic frameworks) in nature are all applicable. With judicious choice of cell membranes, these nanotherapeutics can achieve targeted delivery to the inflammatory environment for enhanced therapeutic efficacy.
Author Hu, Hanze
Lao, Yeh‐Hsing
Shao, Dan
Li, Mingqiang
Yan, Huize
Leong, Kam W.
AuthorAffiliation 4 Department of System Biology Columbia University Medical Center New York NY 10032 USA
1 Department of Biomedical Engineering Columbia University New York NY 10027 USA
2 Guangdong Provincial Key Laboratory of Liver Disease The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong 510630 China
3 Institutes of Life Sciences School of Biomedical Science and Engineering and National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou International Campus Guangzhou Guangdong 510006 China
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– name: 4 Department of System Biology Columbia University Medical Center New York NY 10032 USA
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Snippet In article number 1900605, Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for...
In article number 1900605 , Dan Shao, Kam W. Leong, and co‐workers summarize recent advances of rationally engineered cell membrane–based nanotherapeutics for...
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SubjectTerms biomimetic nanomedicine
cell membrane engineering
Cover Picture
inflammation
inflammatory microenvironment
targeted drug delivery
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Title Nanotherapeutics: Engineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation (Adv. Sci. 15/2019)
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https://pubmed.ncbi.nlm.nih.gov/PMC6685476
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