Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease

Those patients with perianal Crohn's disease or ulcerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulator...

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Published inWorld journal of transplantation Vol. 8; no. 4; pp. 97 - 101
Main Authors Dailey, Francis E, Turse, Erica P, Naseer, Maliha, Bragg, Jack D, Tahan, Veysel
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 09.08.2018
Subjects
Minireviews
Inflammatory bowel disease
Fistula
Perianal disease
Stem cells
Crohn’s disease
Mesenchymal
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Summary:Those patients with perianal Crohn's disease or ulcerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids, antibiotics, immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.
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Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Correspondence to: Veysel Tahan, FACG, FACP, FESBGH, MD, Assistant Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri Health Center, One Hospital Drive, CD 405, Columbia, MO 65212, United States. tahanv@health.missouri.edu
Telephone: +1-573-8846044 Fax: +1-573-8844595
ISSN:2220-3230
2220-3230
DOI:10.5500/wjt.v8.i4.97