News in the studies of multidrug resistance of breast cancer cells

• Published in: Uspehi molekulârnoj onkologii Vol. 2; no. 1; pp. 39 - 051
• Main Authors: Stavrovskaya, A. A., Guens, G. P.
• Format: Journal Article
• Language: English
• Published: ABV-press 02.06.2015
• Subjects: biological tumor markers; breast cancer; multidrug resistance; transporters of abc family; tumor progression; tumor stem cells
• ISSN: 2313-805X; 2413-3787
• DOI: 10.17650/2313-805X.2015.2.1.039-051

Breast cancer (BC) is the most common cancer among women in Russia. One of the main treatment methods of BC is systemic chemotherapy. Multidrug resistance of tumor cells (MDR) is the important hindrance on the way to successful chemotherapy. The new data concerning molecular mechanisms of MDR will be presented in this review. The recent data concerning some new biological prognostic markers will be also discussed. There are data showing that transporters of ABC family (ABC transporters) influence tumor progression not only by MDR induction but also by the influence on the traits of malignancy in tumor cells. The results of the studies of ABC transporters, participation in the processes of accumulation of tumor stem cells under the influence of chemotherapy will be discussed. The problem of the participation of ABC transporters in the phenomenon of influence of PI3K/AKT/PTEN signal transduction pathway on the MDR regulation is discussed. The results of the studies of the role of microRNA deregulation in breast cancer drug resistance as well as studies of some epigenetic mechanisms of MDR regulation will be considered. Protein phosphatase 2A (PP2A, serine/threonine phosphatase), PTK7 (protein tyrosine kinase 7). fascin (an actin bundling cytoskeletal protein) multifunctional YB-1 protein will considered as new BC prognostic markers. The perspectives of MDR studies will be discussed as well.