Assembly properties of complex drug delivery systems

The interaction of materials within the context of a formulation and its manufacturing process can have a defining impact on a parenteral drug product performance. Therefore, establishment of methodologies to investigate the interactions of drug substance with itself and other components can be a cr...

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Bibliographic Details
Published inBritish Journal of Pharmacy Vol. 8; no. 2; pp. S1 - S2
Main Authors Treacher, Kevin Edward, Capomaccio, Robin Bruno
Format Journal Article
LanguageEnglish
Published Huddersfield, United Kingdom University of Huddersfield Press 01.12.2023
Subjects
complex characterisation
Morphology
morphology digital twin
nanoimaging
Nanomedicine
nanomedicines
Polymeric drug delivery systems
Protozoa
Technique
Transmission electron microscopy
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Summary:The interaction of materials within the context of a formulation and its manufacturing process can have a defining impact on a parenteral drug product performance. Therefore, establishment of methodologies to investigate the interactions of drug substance with itself and other components can be a critical aspect of developing a product and understanding its potential failure modes. This paper will discuss some of the methodologies used to investigate assembly properties of different delivery systems, including separation techniques combined with on-line multiple detectors, and nanoscale imaging. Examples where the data are combined with modelling the morphology demonstrate the strength of combining multiple experiments with calculations to provide deeper insight into functionality for e.g. polymeric nanoparticles and drug dendrimer conjugates.
Bibliography:British Journal of Pharmacy, Vol. 8, No. 2, Dec 2023, S1-S2
Informit, Melbourne (Vic)
ISSN:2058-8356
2058-8356
DOI:10.5920/bjpharm.1350