The isoprostane, 8-epi-PGF2α, is accumulated in coronary arteries isolated from patients with coronary heart disease

• Published in: Cardiovascular research Vol. 43; no. 2; pp. 492 - 499
• Main Authors: MOHAMMAD REZA MEHRABI, EKMEKCIOGLU, C, TATZBER, F, OGUOGHO, A, ULLRICH, R, MORGAN, A, TAMADDON, F, GRIMM, M, GLOGAR, H. D, SINZINGER, H
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.08.1999
• Subjects: Analysis of Variance; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathy, Dilated - metabolism; Coronary Disease - metabolism; Coronary Disease - surgery; Coronary heart disease; Coronary Vessels - chemistry; Heart; Heart Transplantation; Humans; Immunohistochemistry; Medical sciences; Middle Aged; Radioimmunoassay; Vascular disease; Human; Immunohistochemistry; Pathology; Prostaglandin; Pathogenesis; Atherosclerosis; Cardiovascular disease; Coronary heart disease; Free radical

In the present study we wanted to know whether 8-epi-PGF2 alpha, which belongs to the class of isoprostanes formed by free radical-mediated peroxidation of arachidonic acid and arachidonyl-containing phospholipids, is enriched in isolated coronary arteries of patients suffering from coronary heart d...