Interventions to Support Adherence to Oral Anticancer Medications: Systematic Review and Meta-Analysis

PROBLEM IDENTIFICATION: This systematic review compared the efficacy of interventions to usual care on adherence to oral anticancer regimens. LITERATURE SEARCH: Embase®, PubMed®, and CINÄHL® were searched for eligible comparative studies published between January 2000 and May 2021. Outcomes of inter...

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Published inOncology nursing forum Vol. 49; no. 4; pp. E4 - E16
Main Authors Waseem, Haya, Ginex, Pamela K, Sivakumaran, Kapeena, DeGennaro, Gina M, Lagler-Clark, Sarah, LeFebvre, Kristine B, Palmer, Nicole, Pasumarthi, Tejanth, Rieger, Paula, Thoele, Kelli, Morgan, Rebecca L
Format Journal Article
LanguageEnglish
Published Pittsburgh Oncology Nursing Society 01.07.2022
Subjects
Automation
Bias
Cancer therapies
Chemotherapy
Decision making
Intervention
Meta-analysis
Oncology
Patient satisfaction
Quality of life
Risk assessment
Software
Systematic review
Taxonomy
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Summary:PROBLEM IDENTIFICATION: This systematic review compared the efficacy of interventions to usual care on adherence to oral anticancer regimens. LITERATURE SEARCH: Embase®, PubMed®, and CINÄHL® were searched for eligible comparative studies published between January 2000 and May 2021. Outcomes of interest included adherence, cancer-related morbidity, quality of life, patient satisfaction, and other patient-specific outcomes. DATA EVALUATION: Reviewers assessed risk of bias using the Cochrane Risk of Bias 2 tool and Risk of Bias in Nonrandomized Studies of Interventions. Certainty of evidence was assessed using the GRADE framework. SYNTHESIS: Risk assessment, ongoing or periodic assessment, proactive follow-up, motivational interviewing, or structured programs may improve adherence. Education or coaching interventions may improve or have little to no effect on adherence. Technological interventions may improve adherence, but interactive compared to noninteractive technology may have little to no effect. IMPLICATIONS FOR RESEARCH: As more cancer treatments move to oral formulations, work remains to identify the most effective interventions to support people receiving oral anticancer regimens.
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ISSN:0190-535X
1538-0688
DOI:10.1188/22.ONF.E4-E16