Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma

• Published in: World journal of otorhinolaryngology - head and neck surgery
• Main Authors: Li, Wen‐Jing, Xu, Xiao‐Lin, Xu, Li‐Cheng, Wang, Shun‐Peng, Dong, Yao‐Yao, Wang, Yi, Ren, Xiao‐Li, Ye, Lei, Liu, Peng‐Yan, Liu, Ming, Tian, Lin‐Li
• Format: Journal Article
• Language: English
• Published: 19.05.2025

HPSCC with elevated IGF‐1R is more likely to spread (e.g., lymph node metastasis) and correlates with poorer survival, especially in p16− cancers. p16+ tumors exhibit stronger antitumor immunity, including higher CD8+ T‐cell infiltration and PD‐L1 expression, and are associated with better survival,...