Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma

HPSCC with elevated IGF‐1R is more likely to spread (e.g., lymph node metastasis) and correlates with poorer survival, especially in p16− cancers. p16+ tumors exhibit stronger antitumor immunity, including higher CD8+ T‐cell infiltration and PD‐L1 expression, and are associated with better survival,...

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Published inWorld journal of otorhinolaryngology - head and neck surgery
Main Authors Li, Wen‐Jing, Xu, Xiao‐Lin, Xu, Li‐Cheng, Wang, Shun‐Peng, Dong, Yao‐Yao, Wang, Yi, Ren, Xiao‐Li, Ye, Lei, Liu, Peng‐Yan, Liu, Ming, Tian, Lin‐Li
Format Journal Article
LanguageEnglish
Published 19.05.2025
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Summary:HPSCC with elevated IGF‐1R is more likely to spread (e.g., lymph node metastasis) and correlates with poorer survival, especially in p16− cancers. p16+ tumors exhibit stronger antitumor immunity, including higher CD8+ T‐cell infiltration and PD‐L1 expression, and are associated with better survival, suggesting suitability for immunotherapy such as PD‐1/PD‐L1 inhibitors. IGF‐1R and p16 status may serve as biomarkers to predict the aggressiveness of HPSCC and guide personalized treatment strategies.
ISSN:2095-8811
2589-1081
DOI:10.1002/wjo2.70025