YY1 in Cell Differentiation and Tissue Development

Yin Yang1 (YY1) is a ubiquitous expressed transcription factor that modulates a variety of biologic processes with prominent roles in cellular differentiation and tissue development. Recent advances in molecular biology, mouse genetics, and particularly high-throughput sequencing have greatly enhanc...

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Bibliographic Details
Published inCritical reviews in oncogenesis Vol. 22; no. 1-2; p. 131
Main Authors Chen, Fengyuan, Sun, Hao, Zhao, Yu, Wang, Huating
Format Journal Article
LanguageEnglish
Published United States 2017
Subjects
Animals
Cell Differentiation - genetics
Gene Expression Regulation, Developmental - genetics
Humans
Immune System - growth & development
Immune System - metabolism
Mice
Muscle Development - genetics
Nerve Tissue - growth & development
Nerve Tissue - metabolism
YY1 Transcription Factor - genetics
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ISSN0893-9675
DOI10.1615/CritRevOncog.2017021311

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Summary:Yin Yang1 (YY1) is a ubiquitous expressed transcription factor that modulates a variety of biologic processes with prominent roles in cellular differentiation and tissue development. Recent advances in molecular biology, mouse genetics, and particularly high-throughput sequencing have greatly enhanced our understanding of YY1 functions and underlying mechanisms in regulating transcription and epigenetics. In this review, we summarize findings on the roles of YY1 in cell differentiation and tissue development, in particular in muscle, nerve, and immune cells/tissues.
ISSN:0893-9675
DOI:10.1615/CritRevOncog.2017021311