Protein kinase Cζ: not-so-innocent bystander or unusual suspect in kidney transplant rejection?

Antibodies against non-HLA targets are increasingly recognized in the context of transplant rejection. However, their specific role remains largely elusive, as evidence exists supporting both their occurrence as an epiphenomenon and their actual pathogenicity in the rejection process. Sutherland et...

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Bibliographic Details
Published inKidney international Vol. 76; no. 12; pp. 1223 - 1224
Main Author Goebel, Jens W.D.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.12.2009
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Summary:Antibodies against non-HLA targets are increasingly recognized in the context of transplant rejection. However, their specific role remains largely elusive, as evidence exists supporting both their occurrence as an epiphenomenon and their actual pathogenicity in the rejection process. Sutherland et al. describe protein kinase Cζ as a novel, non-HLA antigenic target in the setting of graft rejection.
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.2009.393