A Case of Crohn's Disease with Huge Perineal Defect that Infliximab was Effective

A 25-year-old man diagnosed with uncontrollable perianal abcess was admitted. At first, we strongly suspected of heaving Crohn. s disease, which was eventually. Later, we confirmed Crohn. s disease pahologically from perinial tissue. The perineum was inveterate, and developed into a huge defect. Aft...

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Published inNippon Shokaki Geka Gakkai zasshi Vol. 40; no. 12; pp. 1950 - 1954
Main Authors Sahara, Rikisaburo, Takahashi, Tomoko, Ohashi, Katsuhisa, Obara, Kunihiko, Yamana, Tetsuro, Furukawa, Satomi, Okada, Daisuke, Okamoto, Kinya, Komura, Kenichi
Format Journal Article
LanguageJapanese
Published The Japanese Society of Gastroenterological Surgery 2007
Subjects
anal fistula
Crohn's disease
infliximab
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ISSN0386-9768
1348-9372
DOI10.5833/jjgs.40.1950

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Abstract A 25-year-old man diagnosed with uncontrollable perianal abcess was admitted. At first, we strongly suspected of heaving Crohn. s disease, which was eventually. Later, we confirmed Crohn. s disease pahologically from perinial tissue. The perineum was inveterate, and developed into a huge defect. After medication by infliximab, intractable pain under morphine and the defect immediately improved. No case has been reported, to our knowledge, that infliximab being effective for a huge perineal defect and uncontrollable pain in Japan.
AbstractList A 25-year-old man diagnosed with uncontrollable perianal abcess was admitted. At first, we strongly suspected of heaving Crohn. s disease, which was eventually. Later, we confirmed Crohn. s disease pahologically from perinial tissue. The perineum was inveterate, and developed into a huge defect. After medication by infliximab, intractable pain under morphine and the defect immediately improved. No case has been reported, to our knowledge, that infliximab being effective for a huge perineal defect and uncontrollable pain in Japan.
Author Okada, Daisuke
Sahara, Rikisaburo
Okamoto, Kinya
Yamana, Tetsuro
Ohashi, Katsuhisa
Obara, Kunihiko
Komura, Kenichi
Takahashi, Tomoko
Furukawa, Satomi
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  fullname: Takahashi, Tomoko
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  fullname: Ohashi, Katsuhisa
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  fullname: Obara, Kunihiko
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  fullname: Yamana, Tetsuro
  organization: Department of Proctology, Social Health Insurance Hospital
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  fullname: Furukawa, Satomi
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  fullname: Okada, Daisuke
  organization: Department of Proctology, Social Health Insurance Hospital
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  fullname: Okamoto, Kinya
  organization: Department of Proctology, Social Health Insurance Hospital
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  fullname: Komura, Kenichi
  organization: Department of Proctology, Social Health Insurance Hospital
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References 8) Pagi C, Gili L, Targuini M et al: Infliximab for severe recurrent crohn. s disease presenting with massive gastrointestinal hemorrhage. J Clin Gastroenterol 35: 238-241, 2003
2) Regueiro M, Mardini H: Treatment of perianal fistulizing Crohn. s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9: 98-103, 2003
7) Tsujikawa T, Nezu R, Andoh A et al: Infliximab as a possible treatment for the hemorrhagic type of crohn. s disease. J Gastroenterol 39: 284-287, 2004
6) Belaiche J, Louis E: Sever lower gastrointestinal bleeding in crohn. s disease: successful control with Infliximab. Am J Gastroenterol 97: 3210-3211, 2002
1) 岡本欣也, 岩垂純一, 奥田哲也ほか: クローン病の肛門病変の診断と治療. 消化器科34: 193-198, 2002
3) Topstad DR, Panaccione R, Heine JA et al: Combined seton placement, infriximab infusion, and maintenance immunosuppressibes improve healing rate in fistlizing anorectal Crohn. s disease: a single center experience. Dis Colon Rectum 46: 577-583, 2003
4) Sands BE, Anderson FH, Bernstein CN et al: Infliximabmaintenance therapy for fistulizing crohn. s disease. N Engl J Med 9: 876-885, 2004
5) van der Hagen SJ, Baeten CG, Soeters PB et al: Anti-TNFα(Infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in crohn. s disease: a preliminary report. Dis Colon Rectum 48: 758 - 767, 2005
9) Lichtenstein GR, Feagan BG, Cohen RD et al: Serious infections and mortality in association with therapies for crohn. s disease: TREAT registry. Clin Gastroenterol Hepatol 4: 621-630, 2006
References_xml – reference: 6) Belaiche J, Louis E: Sever lower gastrointestinal bleeding in crohn. s disease: successful control with Infliximab. Am J Gastroenterol 97: 3210-3211, 2002
– reference: 2) Regueiro M, Mardini H: Treatment of perianal fistulizing Crohn. s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9: 98-103, 2003
– reference: 8) Pagi C, Gili L, Targuini M et al: Infliximab for severe recurrent crohn. s disease presenting with massive gastrointestinal hemorrhage. J Clin Gastroenterol 35: 238-241, 2003
– reference: 7) Tsujikawa T, Nezu R, Andoh A et al: Infliximab as a possible treatment for the hemorrhagic type of crohn. s disease. J Gastroenterol 39: 284-287, 2004
– reference: 3) Topstad DR, Panaccione R, Heine JA et al: Combined seton placement, infriximab infusion, and maintenance immunosuppressibes improve healing rate in fistlizing anorectal Crohn. s disease: a single center experience. Dis Colon Rectum 46: 577-583, 2003
– reference: 5) van der Hagen SJ, Baeten CG, Soeters PB et al: Anti-TNFα(Infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in crohn. s disease: a preliminary report. Dis Colon Rectum 48: 758 - 767, 2005
– reference: 4) Sands BE, Anderson FH, Bernstein CN et al: Infliximabmaintenance therapy for fistulizing crohn. s disease. N Engl J Med 9: 876-885, 2004
– reference: 9) Lichtenstein GR, Feagan BG, Cohen RD et al: Serious infections and mortality in association with therapies for crohn. s disease: TREAT registry. Clin Gastroenterol Hepatol 4: 621-630, 2006
– reference: 1) 岡本欣也, 岩垂純一, 奥田哲也ほか: クローン病の肛門病変の診断と治療. 消化器科34: 193-198, 2002
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Snippet A 25-year-old man diagnosed with uncontrollable perianal abcess was admitted. At first, we strongly suspected of heaving Crohn. s disease, which was...
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StartPage 1950
SubjectTerms anal fistula
Crohn's disease
infliximab
Title A Case of Crohn's Disease with Huge Perineal Defect that Infliximab was Effective
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