Synthesis and Evaluation of Cytotoxicity Effect of New Ligand (LBe) and it's Complexes on a Cervical Cancer

In this research, new ligand (LBe) 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e] indol-2-ylidene) propane-1,3-diylidene) bis(azanylylidene) diphenol was synthesized by the condensation reaction of 2-hydoxy aniline with 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde (Be) in ratio 2:1...

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Bibliographic Details
Published inOriental journal of chemistry Vol. 35; no. 3; pp. 1208 - 1214
Main Authors Hameed, Reham Faek, Jarullah, Areej Ali, Faraj, Fadhil Lafta
Format Journal Article
LanguageEnglish
Published Bhopal Oriental Scientific Publishing Company 01.01.2019
Subjects
Aniline
Cancer
Cervical cancer
Chemistry
Coordination compounds
Copper
Decomposition
Ethanol
Inorganic chemistry
Ligands
Magnetic permeability
Manganese
Metal chlorides
Nickel
NMR spectroscopy
Organic chemistry
Science
Toxicity
Zinc chloride
New York
United States > US
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Summary:In this research, new ligand (LBe) 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e] indol-2-ylidene) propane-1,3-diylidene) bis(azanylylidene) diphenol was synthesized by the condensation reaction of 2-hydoxy aniline with 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde (Be) in ratio 2:1. (LBe) was used as ligand to synthesis a series of metal complexes by its reaction with different metal chlorides in a molar ratio 1:1 and 1:2 of M:L in ethanol such as (NiCl2.6H2O, CuCl2.2H2O, CoCl2.6H2O, MnCl2.4H2O and ZnCl2). The chemical structures of the ligand and its complexes were characterized by 1H-NMR spectroscopy, infrared spectroscopy, ultra violet-visible spectroscopy, magnetic susceptibility, and molar conductivity measurements. According to the results obtained the suggested structures of the complexes, Square planar geometry for [Co(LBe)], [Ni(LBe)], [Cu(LBe)], octahedral geometry for [Mn(LBe)] and tetrahedral geometry for [Zn(LBe)2]. Cytotoxicity effect of ligand LBe and its complexes have been evaluated against Hella cell line (cervical cancer) in two exposure times 24 and 48 hrs.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/350342