The effects of phenobarbital and carbon tetrachloride on the rate of decline of body burdens of hexachlorobenzene in the rat

Plasma cholinesterase activity in rats raised on diets of hexachlorobenzene and then placed on a hexachlorobenzene-free diet and dosed with eit treatment as were liver aniline hydroxylase and N-demethylase activities. Phenobarbital treatment increased liver aniline hydroxylase and N-demethylase acti...

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Published inArchives of environmental contamination and toxicology Vol. 2; no. 3; pp. 243 - 252
Main Authors Villeneuve, D C, Phillips, W E, Panopio, L G, Mendoza, C E, Hatina, G V, Grant, D L
Format Journal Article
LanguageEnglish
Published United States 1974
Subjects
Aminopyrine N-Demethylase - metabolism
Aniline Compounds
Animals
Body Burden
Carbon Tetrachloride - pharmacology
Chemical and Drug Induced Liver Injury - metabolism
Chlorobenzenes - poisoning
Cholinesterases - blood
Diet
Drug Synergism
Enzyme Induction - drug effects
Female
Kinetics
Liver - analysis
Male
Microsomes, Liver - enzymology
Mixed Function Oxygenases - blood
Organ Size
Pesticide Residues - analysis
Phenobarbital - pharmacology
Rats
Time Factors
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Summary:Plasma cholinesterase activity in rats raised on diets of hexachlorobenzene and then placed on a hexachlorobenzene-free diet and dosed with eit treatment as were liver aniline hydroxylase and N-demethylase activities. Phenobarbital treatment increased liver aniline hydroxylase and N-demethylase activities. No direct correlation was observed between induction of enzyme activity and rate of hexachlorobenzene residue disappearance in liver tissue.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0090-4341
1432-0703
DOI:10.1007/BF01956173