Anti-tumor effects of prostaglandin D2 and its metabolites, 15-deoxy-Δ12, 14-PGJ2, by peroxisome proliferator-activated receptor (PPAR) γ-dependent and -independent pathways
Hematopoietic prostaglandin (PG) D synthase (H-PGDS) is known as key enzyme in the production of PGD2 and its J series metabolite, 15-deoxy-Δ12, 14-PGJ2 (15d-PGJ2), is thought to play an important role for anti-inflammatory effects. Anti-tumor effects of 15d-PGJ2 has been shown to be involved in bot...
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Published in | Inflammation and Regeneration Vol. 31; no. 2; pp. 189 - 195 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
The Japanese Society of Inflammation and Regeneration
2011
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Subjects | |
Online Access | Get full text |
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Summary: | Hematopoietic prostaglandin (PG) D synthase (H-PGDS) is known as key enzyme in the production of PGD2 and its J series metabolite, 15-deoxy-Δ12, 14-PGJ2 (15d-PGJ2), is thought to play an important role for anti-inflammatory effects. Anti-tumor effects of 15d-PGJ2 has been shown to be involved in both peroxisome proliferator-activated receptor (PPAR) γ independent and dependent pathways. The independent pathway includes the repression of the telomerase reverse transcriptase (TERT) and cyclooxygenase (COX)-2 via the down-regulation of NFκB. The dependent pathway included repression of the vascular endothelial growth factor (VEGF) receptors and COX-2 with down-regulation of NFκB, followed by the activation of PPAR γ. In this review, we focused on the role of 15d-PGJ2 in anti-tumor effects including our evaluation in mouse bladder carcinoma model. |
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ISSN: | 1880-9693 1880-8190 |
DOI: | 10.2492/inflammregen.31.189 |