GW27-e0158 Tirofiban protects against myocardial ischemia and reperfusion injury in mice

Methods Tirofiban effects were evaluated in mouse heart preparation using 30-min coronary occlusion followed by 24-h reperfusion and compared among SHAM group (negative model control, n=7), I/R group (positive model control, n=8), VER (I/R with verapamil 20mg/kg pretreatment, positive drug control,...

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 68; no. 16; p. C5
Main Authors Jianyong, Qi, Zhang, Minzhou
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 18.10.2016
Elsevier Limited
Subjects
Cardiology
Cardiovascular
Heart attacks
Internal Medicine
Ischemia
Rodents
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Summary:Methods Tirofiban effects were evaluated in mouse heart preparation using 30-min coronary occlusion followed by 24-h reperfusion and compared among SHAM group (negative model control, n=7), I/R group (positive model control, n=8), VER (I/R with verapamil 20mg/kg pretreatment, positive drug control, n=6), and TIR (I/R with tirofiban 5mg/kg pretreatment, the aim group,n=8).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.07.019