Microwave-Assisted, Metal-Free, Chemoselective N-Formylation of Amines using 2-Formyl-1,3-dimethyl-1H-imidazol-3-ium Iodide and In Situ Synthesis of Benzimidazole and Isocyanides
Abstract An efficient, environmentally benign, chemoselective, microwave-assisted N -formylation protocol of aromatic, aliphatic, alicyclic, benzylic amines, inactivated aromatic amines and sterically demanding heterocyclic amines using 2-formyl-1,3-dimethyl-1 H -imidazol-3-ium iodide has been devel...
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Published in | SynOpen (2017) Vol. 6; no. 2; pp. 132 - 140 |
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Main Authors | , , , |
Format | Journal Article |
Language | French English |
Published |
Rüdigerstraße 14, 70469 Stuttgart, Germany
Georg Thieme Verlag KG
01.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract
An efficient, environmentally benign, chemoselective, microwave-assisted
N
-formylation protocol of aromatic, aliphatic, alicyclic, benzylic amines, inactivated aromatic amines and sterically demanding heterocyclic amines using 2-formyl-1,3-dimethyl-1
H
-imidazol-3-ium iodide has been developed. This affords a series of
N
-substituted formamides with good to excellent yields (23 examples, 53–96% yield) and can be readily scaled. The methodology can be further extended to synthesize benzimidazole and isocyanide derivatives. |
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ISSN: | 2509-9396 2509-9396 |
DOI: | 10.1055/s-0041-1737605 |