Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013)

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 9; no. 24; p. 4149
• Main Authors: Li, Chunxia, Yang, Dongmei, Ma, Ping'an, Chen, Yinyin, Wu, Yuan, Hou, Zhiyou, Dai, Yunlu, Zhao, Jihong, Sui, Changping, Lin, Jun
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 20.12.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: drug delivery; Drug delivery systems; Imaging; Magnetic resonance imaging; Nanocomposites; Nanomaterials; Nanostructure; Nanotechnology; Surgical implants; Upconversion; upconversion cell imaging; upconversion mesoporous silica
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201370154

Incorporating the agents for magnetic resonance imaging (MRI), optical imaging and therapy in one nanostructured matrix to construct a multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. A facile methodology is reported on page 4150 by J. Lin and co‐workers to construct a multifunctional nanocarrier composed of individual luminescent/magnetic β‐NaYF4:Yb3+, Er3+@β‐NaGdF4:Yb3+ directly coated with mesoporous silica, followed by functionalization with poly(ethylene glycol), which can act as an effective platform for upconversion luminescence and magnetic resonance dual‐modal imaging and in vivo anticancer drug delivery.