Effects of cell morphology and electrical properties on electric field and dielectrophoretic force generated in cell exposed to tumor-treating field

Abstract Tumor-treating field (TTF) therapy has been receiving attention as a new minimally invasive treatment for cancer. In this treatment, an alternating electric field applied to target cells inhibits cell division by a dielectrophoretic force acting on chromosomes and microtubules. Previous stu...

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Published inIOP conference series. Materials Science and Engineering Vol. 1096; no. 1; p. 12003
Main Authors Kurata, K, Iwata, T, Shimada, K, Takamatsu, H
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.03.2021
Subjects
Cell division
Chromosomes
Dielectrophoresis
Electric fields
Electrical properties
Finite element method
Morphology
Three dimensional models
Tumors
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Summary:Abstract Tumor-treating field (TTF) therapy has been receiving attention as a new minimally invasive treatment for cancer. In this treatment, an alternating electric field applied to target cells inhibits cell division by a dielectrophoretic force acting on chromosomes and microtubules. Previous studies have shown that an extremely weak electric field of only a few volts per centimeter interferes with chromosome migration and spindle formation. However, the therapeutic range of TTF treatment is still limited. To increase the efficacy of the treatment, the electric field to the target cells must be optimized. Therefore, the aim of this study was to investigate the effect of the electric field frequency, cell morphology, and electrical properties on the outcome of TTF treatment. Three-dimensional finite element models of a sphere and dividing cell were developed, and the distributions of the electric field and dielectrophoretic force were calculated.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/1096/1/012003