Trimethylsilyl chloride catalyzed synthesis of fluoro substituted tetrahydropyrimidines: Molecular docking and antidiabetic studies

A novel series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave the highest yield...

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Bibliographic Details
Published inChemical Data Collections Vol. 41; p. 100904
Main Authors Pansuriya, Ketan, Lalpara, Jaydeep N., Hadiyal, Sanjay D., Dhaduk, B.B., Dubal, G.G.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2022
Subjects
Antidiabetic activity
Molecular docking
Tetrahydropyrimidines
Trimethylsilyl chloride
Tetrahydropyrimidines
Antidiabetic activity
Trimethylsilyl chloride
Molecular docking
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Summary:A novel series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave the highest yield. Moreover, all synthesized molecules were checked for in vitro antidiabetic potential. In addition, molecular docking of these synthesized molecules was studied using barley alpha-amylase isozyme 1 (amy1) (1RPK). The result revealed that compounds 4a and 4c have a good inhibitory potential. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2022.100904