Further toxicologic studies with commercial and candidate flame retardant chemicals. Part II

A number of commercial and candidate flame retardants were studied with regard to their toxicity to goldfish, inhibition of cholinesterase, inhibition of acetyl choline binding to its receptor and insecticidal properties. Several of the flame retardants were notably toxic to fish. Some of the compou...

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Bibliographic Details
Published inBulletin of environmental contamination and toxicology Vol. 17; no. 6; p. 720
Main Authors Eldefrawi, A T, Mansour, N A, Brattsten, L B, Ahrens, V D, Lisk, D J
Format Journal Article
LanguageEnglish
Published United States 01.06.1977
Subjects
Acetylcholine - metabolism
Aniline Compounds
Animals
Cholinesterase Inhibitors
Electric Organ - enzymology
Electric Organ - metabolism
Fires - prevention & control
Fishes
Goldfish
Houseflies - drug effects
Hydrocarbons, Brominated - pharmacology
Hydrocarbons, Brominated - toxicity
In Vitro Techniques
Insecta - drug effects
Insecta - enzymology
Lethal Dose 50
Microsomes - enzymology
Organophosphorus Compounds - pharmacology
Organophosphorus Compounds - toxicity
Oxidoreductases, N-Demethylating - antagonists & inhibitors
Receptors, Cholinergic - metabolism
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Summary:A number of commercial and candidate flame retardants were studied with regard to their toxicity to goldfish, inhibition of cholinesterase, inhibition of acetyl choline binding to its receptor and insecticidal properties. Several of the flame retardants were notably toxic to fish. Some of the compounds showed modest inhibition of cholinesterase and/or microsomal oxidases, but none inhibited acetyl choline receptor binding. Whereas several of the flame retardants showed little or no insecticidal properties when added alone to a housefly diet, piperonyl butoxide greatly synergised their toxicity to houseflies.
ISSN:0007-4861
DOI:10.1007/BF01685960