Synthetic surfactant: primary data
Abstract Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse...
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| Published in | Early human development Vol. 89; pp. S111 - S112 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ireland Ltd
01.10.2013
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| Abstract | Abstract Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse at end expiration, even if no positive end-expiratory pressure is applied. The stabilising effect seems to depend on the structure of the peptides as well as the phospholipid composition. Thus, optimal synthetic surfactants containing two peptides combined with a complex phospholipid composition seem to be ideal to replace natural surfactants within a near future. |
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| AbstractList | Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse at end expiration, even if no positive end-expiratory pressure is applied. The stabilising effect seems to depend on the structure of the peptides as well as the phospholipid composition. Thus, optimal synthetic surfactants containing two peptides combined with a complex phospholipid composition seem to be ideal to replace natural surfactants within a near future. Abstract Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse at end expiration, even if no positive end-expiratory pressure is applied. The stabilising effect seems to depend on the structure of the peptides as well as the phospholipid composition. Thus, optimal synthetic surfactants containing two peptides combined with a complex phospholipid composition seem to be ideal to replace natural surfactants within a near future. |
| Author | Curstedt, Tore |
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| Cites_doi | 10.1152/japplphysiol.00865.2007 10.1542/peds.2004-2231 10.1371/journal.pone.0039392 10.1159/000349942 10.1152/japplphysiol.00153.2003 10.1164/rccm.201009-1424OC 10.1371/journal.pone.0047631 10.1111/j.1432-1033.1997.00675.x 10.3109/01902148509069678 10.1152/japplphysiol.91591.2008 |
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| References | Spragg, Taut, Lewis, Schenk, Ruppert, Dean, Krell, Karabinis, Günther (bib7) 2011; 183 Johansson, Some, Linderholm, Almlén, Curstedt, Robertson (bib6) 2003; 95 Sato, Ikegami (bib9) 2012; 7 Johansson, Curstedt (bib2) 1997; 244 Siew, te Pas, Wallace, Kitchen, Lewis, Fouras, Morley, Davis, Yagi, Uesugi, Hooper (bib5) 2009; 106 Berggren, Curstedt, Grossmann, Nilsson, Robertson (bib1) 1985; 8 Seehase, Collins, Kuypers, Jellema, Ophelders, Ospina, Perez-Gil, Bianco, Garzia, Razzetti, Kramer (bib10) 2012; 7 Curstedt, Andrea, Johansson (bib3) 2013; 103 Almlén, Stichtenoth, Linderholm, Haegerstrand-Björkman, Robertson, Johansson, Curstedt (bib4) 2008; 104 Sinha, Lacaze-Masmonteil, Valls-i-Soler, Wiswell, Gadzinowski, Hajdu, Bernstein, Sanchez-Luna, Segal, Schaber, Massaro, d'Agostino (bib8) 2005; 115 Johansson (10.1016/S0378-3782(13)70121-X_bib2) 1997; 244 Seehase (10.1016/S0378-3782(13)70121-X_bib10) 2012; 7 Berggren (10.1016/S0378-3782(13)70121-X_bib1) 1985; 8 Sinha (10.1016/S0378-3782(13)70121-X_bib8) 2005; 115 Curstedt (10.1016/S0378-3782(13)70121-X_bib3) 2013; 103 Almlén (10.1016/S0378-3782(13)70121-X_bib4) 2008; 104 Spragg (10.1016/S0378-3782(13)70121-X_bib7) 2011; 183 Sato (10.1016/S0378-3782(13)70121-X_bib9) 2012; 7 Johansson (10.1016/S0378-3782(13)70121-X_bib6) 2003; 95 Siew (10.1016/S0378-3782(13)70121-X_bib5) 2009; 106 |
| References_xml | – volume: 104 start-page: 1101 year: 2008 end-page: 1108 ident: bib4 article-title: Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome publication-title: J Appl Physiol contributor: fullname: Curstedt – volume: 7 start-page: e39392 year: 2012 ident: bib9 article-title: SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung publication-title: PLoS ONE contributor: fullname: Ikegami – volume: 244 start-page: 675 year: 1997 end-page: 693 ident: bib2 article-title: Molecular structures and interactions of pulmonary surfactant components publication-title: Eur J Biochem contributor: fullname: Curstedt – volume: 95 start-page: 2055 year: 2003 end-page: 2063 ident: bib6 article-title: A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits 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gives survival benefit after inactivation in preterm lambs publication-title: PloS ONE contributor: fullname: Kramer – volume: 103 start-page: 327 year: 2013 end-page: 330 ident: bib3 article-title: New generation synthetic surfactants publication-title: Neonatology contributor: fullname: Johansson – volume: 106 start-page: 1487 year: 2009 end-page: 1493 ident: bib5 article-title: Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth publication-title: J Appl Physiol contributor: fullname: Hooper – volume: 104 start-page: 1101 year: 2008 ident: 10.1016/S0378-3782(13)70121-X_bib4 article-title: Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00865.2007 contributor: fullname: Almlén – volume: 115 start-page: 1030 year: 2005 ident: 10.1016/S0378-3782(13)70121-X_bib8 article-title: A multicenter, randomized, controlled trial of lucinactant versus poractant alfa among very premature infants at high risk for respiratory distress syndrome publication-title: Pediatrics doi: 10.1542/peds.2004-2231 contributor: fullname: Sinha – volume: 7 start-page: e39392 issue: 7 year: 2012 ident: 10.1016/S0378-3782(13)70121-X_bib9 article-title: SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung publication-title: PLoS ONE doi: 10.1371/journal.pone.0039392 contributor: fullname: Sato – volume: 103 start-page: 327 year: 2013 ident: 10.1016/S0378-3782(13)70121-X_bib3 article-title: New generation synthetic surfactants publication-title: Neonatology doi: 10.1159/000349942 contributor: fullname: Curstedt – volume: 95 start-page: 2055 year: 2003 ident: 10.1016/S0378-3782(13)70121-X_bib6 article-title: A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00153.2003 contributor: fullname: Johansson – volume: 183 start-page: 1055 year: 2011 ident: 10.1016/S0378-3782(13)70121-X_bib7 article-title: Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201009-1424OC contributor: fullname: Spragg – volume: 7 start-page: e47631 issue: 10 year: 2012 ident: 10.1016/S0378-3782(13)70121-X_bib10 article-title: New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs publication-title: PloS ONE doi: 10.1371/journal.pone.0047631 contributor: fullname: Seehase – volume: 244 start-page: 675 year: 1997 ident: 10.1016/S0378-3782(13)70121-X_bib2 article-title: Molecular structures and interactions of pulmonary surfactant components publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1997.00675.x contributor: fullname: Johansson – volume: 8 start-page: 29 year: 1985 ident: 10.1016/S0378-3782(13)70121-X_bib1 article-title: Physiological activity of pulmonary surfactant with low protein content: effect of enrichment with synthetic phospholipids publication-title: Exp Lung Res doi: 10.3109/01902148509069678 contributor: fullname: Berggren – volume: 106 start-page: 1487 year: 2009 ident: 10.1016/S0378-3782(13)70121-X_bib5 article-title: Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth publication-title: J Appl Physiol doi: 10.1152/japplphysiol.91591.2008 contributor: fullname: Siew |
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| Title | Synthetic surfactant: primary data |
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