Synthetic surfactant: primary data

Abstract Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse...

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Bibliographic Details
Published inEarly human development Vol. 89; pp. S111 - S112
Main Author Curstedt, Tore
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 01.10.2013
Subjects
Advanced Basic Science
Neonatal and Perinatal Medicine
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Summary:Abstract Treatment of premature newborn rabbits with synthetic surfactants containing both an SP-B and an SP-C analogue in a simple phospholipid mixture has similar tidal volumes as those treated with animal-derived surfactant preparations and will also to some extent prevent the alveoli to collapse at end expiration, even if no positive end-expiratory pressure is applied. The stabilising effect seems to depend on the structure of the peptides as well as the phospholipid composition. Thus, optimal synthetic surfactants containing two peptides combined with a complex phospholipid composition seem to be ideal to replace natural surfactants within a near future.
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(13)70121-X