Antioxidant defense systems in newborns undergoing phototherapy

This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell ant...

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Bibliographic Details
Published inIndian journal of pediatrics Vol. 66; no. 5; pp. 651 - 655
Main Authors AKISÜ, M, YILMAZ, D, TÜZÜN, S, KÜLTÜRSAY, N
Format Journal Article
LanguageEnglish
Published Heidelberg Springer 01.09.1999
Subjects
Biological and medical sciences
Humans
Infant, Newborn
Infant, Premature
Jaundice, Neonatal - blood
Jaundice, Neonatal - therapy
Medical sciences
Miscellaneous
Oxidative Stress
Phototherapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Glutathione peroxidase
Human
Jaundice
Premature
Oxidative stress
Enzyme
Hepatic disease
Superoxide dismutase
E-Vitamins
Antioxidant
Phototherapy
Blood plasma
Prospective
Hyperbilirubinemia
Newborn
Treatment
Peroxidases
Enzymatic activity
Catalase
Digestive diseases
Influence
Oxidoreductases
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Summary:This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell anti-oxidation enzymes (superoxide dismutase, catalase and glutathione peroxidase) before and after 72 h of phototherapy. Serum vitamin E levels were not different before and after 72 h of phototherapy in both preterm and term infants. In several studies, antioxidant enzyme activities have been shown to increase in response to oxidative stresses. In this study, however, the antioxidant enzyme activities in the hemolysate were similar before and at the end of the phototherapy in both preterm and full term. In conclusion, the results of our in vivo study do not confirm the thesis that phototherapy is an oxidative stress in newborn infants. Therefore, phototherapy would preferably seem to be safe and efficient method of treatment for all neonates presenting with hyperbilirubinemia.
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ISSN:0019-5456
0973-7693
DOI:10.1007/BF02726243