Adenosine Receptors and Mammalian Toll-Like Receptors: Synergism in Macrophages
Adenosine is known to participate in tissue protection subsequent to ischemic events. New evidence points to a role for adenosine in promoting neovascularization through a mechanism that requires interaction with the Toll-like receptor (TLR) signaling pathway. In macrophages, the adenosine receptor...
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Published in | Molecular interventions Vol. 3; no. 7; pp. 370 - 374 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.10.2003
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Subjects | |
Online Access | Get full text |
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Summary: | Adenosine is known to participate in tissue protection subsequent to ischemic events. New evidence points to a role for adenosine
in promoting neovascularization through a mechanism that requires interaction with the Toll-like receptor (TLR) signaling
pathway. In macrophages, the adenosine receptor subtype 2A (A 2A R) synergizes with some but not all of the Toll-like receptors, leading to increased expression of vascular endothelial growth
factor (VEGF). Simultaneously, the expression of tumor necrosis factorâα (TNFα) is decreased; this phenomenon depends on the
presence of AR agonists; however, the activation of transcription factor nuclear factorâκB (NFâκB) is not attenuated in the
presence of A 2A R agonists. It appears that the addition of adenosine or other A 2A R agonists can mediate the âangiogenic switch,â in macrophages, from TNFα protein expression to expression of components necessary
for angiogenesis. Although these observations might have important implications for wound healing, it will be important to
discern whether this interaction between ARs and TLRs is necessary for angiogenesis associated with tumor growth. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1534-0384 1543-2548 |
DOI: | 10.1124/mi.3.7.370 |