Robust fabrication of poly(lactic acid) membrane with good hemocompatibility over heparin‐mimetic graphene‐based nanosheets

• Published in: Journal of applied polymer science Vol. 140; no. 8
• Main Authors: Huang, Lilan, Ma, Lankun, Chen, Haimei, Qiao, Lei, Zhang, Leitao, Pan, Jian, Li, Jinwei, Zhang, Yuzhong
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 20.02.2023; Wiley Subscription Services, Inc
• Subjects: Dopamine; Electronegativity; Graphene; hemocompatibility; Hemodialysis; Heparin; heparin‐mimetic; Materials science; Membranes; Nanosheets; poly(lactic acid) membrane; Polylactic acid; Polymers; Serum albumin; sulfonated graphene oxide; Sulfonic acid
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.53507

Developing dislysis membranes with outstanding hemocompatibility is the key of hemodialysis used for curing the kidney malfunction. Herein, polylactic acid (PLA) membrane with high water flux (640.2 L m−2 h−1) and bovine serum albumin (BSA) rejection (>97%) is prepared and subsequently modified by heparin‐mimetic sulfonated graphene oxide (SGO) via modified mussel‐inspired method. The (NH4)2Fe(SO4)2 serves as Fenton catalyst significantly accelerates the oxidized polymerization of dopamine (DA) in DA‐g‐SGO to form polydopamine‐g‐SGO (PDA‐g‐SGO). The uniform immobilization of SGO significantly improves the hydrophilicity and electronegativity of the PLA membranes, inhibiting platelets adhesion. Moreover, the sulfonic group of SGO plays the role of anticoagulant as heparin. The obtained PLA/PDA‐g‐SGO membrane exhibits excellent hemocompatibility with longer recalcification time (230 s) and lower hemolysis ratio (1.6%) than those of original PLA membrane (120 s, 10.7%). This study demonstrates a potential way to improve the hemocompatibility of polymeric membranes. Polylactic acid (PLA) membrane with high water flux and BSA rejection is prepared and subsequently modified by heparin‐mimetic sulfonated graphene oxide (SGO) via modified mussel‐inspired method. The uniform immobilization of SGO significantly improves the hydrophilicity and electronegativity of the PLA membranes, inhibiting platelets adhesion. The obtained PLA/PDA‐g‐SGO membrane exhibits excellent hemocompatibility.