Aortic valve hemodynamic characteristics after the Ozaki procedure according to echocardiography: a multicenter retrospective study

• Published in: Rossiĭskiĭ kardiologicheskiĭ zhurnal Vol. 29; no. 1S; p. 5636
• Main Authors: Rashidova, T. K., Enginoev, S. T., Chernov, I. I., Kolesnikov, V. N., Komarov, R. N., Belov, V. A., Gamzaev, A. B., Arutyunyan, V. B., Kadyraliev, B. K., Semagin, A. P., Kuznetsov, D. V., Zybin, A. A., Tlisov, B. M., Kalinina, M. L., Konovalov, N. S., Bolurova, A. M., Dzhambieva, M. N., Skorodumova, E. G.
• Format: Journal Article
• Language: English; Russian
• Published: FIRMA «SILICEA» LLC 01.04.2024
• Subjects: acquired heart disease; aortic regurgitation; aortic stenosis; aortic valve; aortic valve neocuspidization; echocardiography; ozaki procedure
• ISSN: 1560-4071; 2618-7620
• DOI: 10.15829/1560-4071-2024-5636

Aim. To evaluate the aortic valve (AV) hemodynamic characteristics after the Ozaki procedure according to echocardiography. Material and methods. The retrospective multicenter study included 277 patients with AV defects who were operated on from January 2017 to June 2022 in five centers in Russia. After the Ozaki procedure, the following endpoints were assessed: immediate echocardiographic results (peak AV gradient, mean AV gradient, AV effective orifice area, aortic regurgitation grade), mid-term clinical (three-year survival rate, three-year freedom from reoperation, three-year freedom from grade ≤2 aortic regurgitation) and echocardiographic results (peak and mean AV gradient, AV effective orifice area, aortic regurgitation grade, AV calcification severity). The median follow-up period was 23 (13-32) months. The mean echocardiography follow-up period was 21±10 months. Results. During the treatment, a decrease in the peak AV gradient was observed from 74±30 mm Hg before surgery up to 12 (8-16) mm Hg one week after surgery, which remained in the mid-term period — 12 (9-15) mm Hg. There was also a decrease in the mean gradient from 40 (27-53) mm Hg before surgery up to 6 (4-8) mm Hg one week after surgery. By the mid-term period, the mean gradient was 6 (4-8) mm Hg. The AV effective orifice area increased from 1 (1-1) cm 2 to 2 (2-2) cm 2 in the mid-term follow-up period. Three-year survival rate was 90,2%, freedom from reoperation was 95%, freedom from grade ³2 aortic regurgitation was 88%, and no patient had AV calcification. Conclusion. The Ozaki procedure in patients with AV defects has good immediate and mid-term hemodynamic parameters according to echocardiography. However, there remains a need for large randomized controlled trials comparing Ozaki procedure with biological AV replacement.