Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

• Published in: Dermatology online journal Vol. 27; no. 10
• Main Authors: Saqlain, Farees, Shalhout, Sophia Z, Wright, Kayla, Miller, David Michael
• Format: Journal Article
• Language: English
• Published: United States University of California Digital Library - eScholarship 15.10.2021
• Subjects: Aged; Biopsy; Cancer; Carcinoma, Basal Cell - pathology; Carcinoma, Merkel Cell - pathology; Carcinoma, Squamous Cell - pathology; Cysts - pathology; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Male; Middle Aged; Retrognathia; Retrospective Studies; Skin - pathology; Skin cancer; Skin Neoplasms - pathology
• ISSN: 1087-2108; 1087-2108
• DOI: 10.5070/D3271055614

Merkel cell carcinoma is an aggressive carcinoma of the skin notable for protean presentation on physical exam. A retrospective cohort of 232 patients with primary cutaneous Merkel cell carcinoma was reviewed for availability of data on pre-biopsy clinical differential diagnosis based on clinical exam. Data was available for 192 patients (83%). The three most common impressions were cyst (33.3%), basal cell carcinoma (31.8%), and squamous cell carcinoma (19.8%). Merkel cell carcinoma was correctly suspected in only 13 cases (6.8%). A greater proportion of lesions that were less than or equal to 2 cm in diameter (10.2%) or carried BCC as a co-diagnosis (11.5%) were correctly suspected as Merkel cell carcinoma prior to biopsy, versus lesions greater than 2 cm in diameter (1.6%) or carrying SCC as a co-diagnosis (2.6%), suggesting that clinicians may be anchoring on the well-publicized concept of Merkel cell carcinoma as a small, pearly papule in real-world practice.