Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?

Introduction: Ischemia/reperfusion damage (IRD) is one of the most important factors in the success of organ transplantation. IRD plays a role in both acute and chronic rejection. This study aims to evaluate the effects of lycopene, which is known to be a powerful antioxidant, on experimental uterin...

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Bibliographic Details
Published inIstanbul medical journal Vol. 22; no. 2; pp. 155 - 160
Main Authors Onat, Taylan, Doğanyiğit, Züleyha, Demir Çaltekin, Melike, Türkler, Can, Kaymak, Emin, Altındağ, Mehmet Murat
Format Journal Article
LanguageEnglish
Published Istanbul Galenos Publishing House 01.05.2021
Galenos Yayinevi
Subjects
Abdomen
Antioxidants
Carotenoids
Humidity
Injury prevention
Ischemia
ischemia/reperfusion damage
Laboratories
lycopene
Neutrophils
organ transplantation
Oxidative stress
Rodents
Transplants & implants
Uterus
Turkey
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Summary:Introduction: Ischemia/reperfusion damage (IRD) is one of the most important factors in the success of organ transplantation. IRD plays a role in both acute and chronic rejection. This study aims to evaluate the effects of lycopene, which is known to be a powerful antioxidant, on experimental uterine IRD. Methods: Twenty-four albino Wistar rats were included in the study and divided into three groups. No substances were administered the sham and ischemia/reperfusion groups. The ischemia/reperfusion and ischemia/reperfusion + lycopene groups were administered ischemia for 1 h and reperfusion for 2 h. The ischemia/reperfusion + lycopene group was administered 2.5 mg/kg lycopene reperfusion intraperitoneally half an hour before ischemia/reperfusion. Both uterine horns were extracted at the end of the procedure. Oxidative stress, inflammation, and apoptosis in the tissues were assessed. Results: The malondialdehyde level, nuclear factor kappa-B immunoreactivity, and apoptotic cell number in the lycopeneadministered group (ischemia/reperfusion + lycopene) were significantly decreased compared with those in the ischemia/ reperfusion group (p<0.05). Conclusion: The study found that lycopene reduced the effects of IRD on uterine tissue. Lycopene may positively affect the short- and long-term success of organ transplantation.
ISSN:2619-9793
1304-8503
2148-094X
DOI:10.4274/imj.galenos.2021.82698