An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats

Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1) in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of...

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Bibliographic Details
Published inMycopathologia (1975) Vol. 120; no. 2; p. 113
Main Authors Cukrová, V, Kurita, N, Akao, M
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.1992
Subjects
Aflatoxin B1 - toxicity
Animals
Bone Marrow - drug effects
Bone Marrow Cells
Cells, Cultured
Colony-Forming Units Assay
Cytokines - biosynthesis
Cytokines - drug effects
Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis
Granulocytes - drug effects
Interleukin-1 - biosynthesis
Interleukin-2 - biosynthesis
Macrophages - drug effects
Macrophages - metabolism
Male
Rats
Rats, Inbred F344
Spleen - cytology
Spleen - drug effects
Spleen - metabolism
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Summary:Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1) in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of LD50 for young male rats. An early suppressive effect of AFB1 towards CFU-GM was transient in treated animals. The peak in granulopoietic activity was preceded in time by an increased CSA and IL-1 formation. Elevated IL-2 synthesis and increased T cell activation paralleled the peak in granulopoietic activity.
ISSN:0301-486X
DOI:10.1007/BF00578296