Re-evaluation of classic senile plaques by three-dimensional analysis

We evaluated the proportion of classic plaques among all of the senile plaques in four Alzheimer brains (frontal, temporal, occipital and hippocampal areas) by the usual method of two-dimensional analysis using a single methenamine silver-stained section and three-dimensional analysis using a set of...

Full description

Saved in:
Bibliographic Details
Published inJournal of neurology Vol. 241; no. 10; p. 624
Main Authors Kimura, T, Hisano, T, Yoshida, H, Ueda, K, Miyakawa, T
Format Journal Article
LanguageEnglish
Published Germany 01.10.1994
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Amyloid beta-Peptides - analysis
Antibodies, Monoclonal
Brain Chemistry
Humans
Immunoenzyme Techniques
Methenamine
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:We evaluated the proportion of classic plaques among all of the senile plaques in four Alzheimer brains (frontal, temporal, occipital and hippocampal areas) by the usual method of two-dimensional analysis using a single methenamine silver-stained section and three-dimensional analysis using a set of serial sections. Three-dimensional analysis showed the number and percentage of classic plaques to be 2-5 times greater than those revealed by two-dimensional analysis. In the hippocampal area of one case, no classic plaques were found by two-dimensional analysis but three-dimensional analysis showed that some classic plaques were present. From these findings, it is suggested that three-dimensional analysis using serial sections is indispensable for subclassifying senile plaques.
ISSN:0340-5354
DOI:10.1007/BF00920628