Bradykinin for the treatment of cardiovascular disease

Bradykinin is a vasoactive kinin known to be involved in many biologic processes. Levels of bradykinin have been shown to be elevated in a number of cardiac diseases. It is thought that these elevated levels play a protective role in cardiovascular diseases. Preliminary studies have demonstrated tha...

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Bibliographic Details
Published inHeart disease (Hagerstown, Md.) Vol. 3; no. 5; p. 333
Main Authors Palkhiwala, S A, Frishman, W H, Warshafsky, S
Format Journal Article
LanguageEnglish
Published United States 01.09.2001
Subjects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Bradykinin - physiology
Bradykinin - therapeutic use
Cardiovascular Diseases - blood
Cardiovascular Diseases - drug therapy
Humans
Receptors, Bradykinin - metabolism
Treatment Outcome
Vasodilator Agents - therapeutic use
Ventricular Remodeling - drug effects
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Summary:Bradykinin is a vasoactive kinin known to be involved in many biologic processes. Levels of bradykinin have been shown to be elevated in a number of cardiac diseases. It is thought that these elevated levels play a protective role in cardiovascular diseases. Preliminary studies have demonstrated that bradykinin may have beneficial effects on a wide spectrum of cardiovascular disorders. Though much study is still required, bradykinin augmentation represents an exciting new target for the treatment of cardiovascular disease.
ISSN:1521-737X
DOI:10.1097/00132580-200109000-00010