Falcarindiol from Angelica koreana Down-regulated IL-8 and Up-regulated IL-10 in Colon Epithelial Cells

Angelica koreana is an important medicinal plant for some locals in East Asia including Korea. A few reports have shown the efficacy of its phytochemical constituents. We have isolated and purified one compound falcarindiol (FAL) from the methanolic extract of A. koreana roots. At concentrations fro...

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Bibliographic Details
Published inNatural product sciences Vol. 23; no. 2; pp. 103 - 107
Main Authors Shim, Sun-Yup, Lee, Seul-gi, Kim, Mihye, Lee, Jin Woo, Hwang, Bang Yeon, Lee, Mina
Format Journal Article
LanguageEnglish
Published 한국생약학회 2017
Subjects
약학
Inflammatory bowel disease
Angelica koreana
Colon epithelial cells
Falcarindiol
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ISSN1226-3907
2288-9027
DOI10.20307/nps.2017.23.2.103

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Summary:Angelica koreana is an important medicinal plant for some locals in East Asia including Korea. A few reports have shown the efficacy of its phytochemical constituents. We have isolated and purified one compound falcarindiol (FAL) from the methanolic extract of A. koreana roots. At concentrations from to 1 mM to 25 mM, the FAL isolated from the roots of A. koreana exerted no significant cytotoxicity and down-regulated LPS-stimulated pro-inflammatory cytokine IL-8 in colon epithelial cells, while up-regulating anti-inflammatory cytokine IL-10. In addition, the FAL decreased the expression of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxy- genase (COX)-2 protein by Western blot analysis. Colon epithelial cells play pivotal roles in regulating the colon immune system and thus FAL is expected to be candidate agent as therapeutic potential for the treatment of inflammatory bowel disease (IBD) by modulating LPS-induced inflammation in colon epithelial cells. KCI Citation Count: 0
ISSN:1226-3907
2288-9027
DOI:10.20307/nps.2017.23.2.103