Dose-response relationship of vindeburnol based on spectral analysis of posturographic recordings

The dose-response relationship of vindeburnol has been investigated by assessing postural activity in a population of elderly patients, using posturography, an objective method for measuring balance. A controlled double blind trial was done in two periods: during the first week each patient received...

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Bibliographic Details
Published inEuropean journal of clinical pharmacology Vol. 29; no. 4; p. 455
Main Authors Patat, A, Le Go, A, Foulhoux, P
Format Journal Article
LanguageEnglish
Published Germany 01.07.1985
Subjects
Aged
Clinical Trials as Topic
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Male
Middle Aged
Postural Balance - drug effects
Posture
Random Allocation
Vinca Alkaloids - pharmacology
Vincamine - administration & dosage
Vincamine - analogs & derivatives
Vincamine - pharmacology
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Summary:The dose-response relationship of vindeburnol has been investigated by assessing postural activity in a population of elderly patients, using posturography, an objective method for measuring balance. A controlled double blind trial was done in two periods: during the first week each patient received placebo, and during the second week either placebo or vindeburnol 30, 60 or 90 mg/d was given. Subjects underwent three posturographic recordings at weekly intervals (prior to treatment, after one week on placebo and after one week of treatment). There was no placebo effect. A significant decrease in the sagittal and lateral energies of body sway was found after vindeburnol, which indicates an improvement in balance. The improvement was proportional to the daily dose of vindeburnol.
ISSN:0031-6970
DOI:10.1007/BF00613461