Management of Hypernatremia Dehydration in Three Neonates with Ichthyosis

• Published in: Majallah-ʼi bīmārīhā-yi kūdakān-i Īrān = Iranian journal of pediatrics Vol. 33; no. 2
• Main Authors: Sangsari, Razieh, Saeedi, Maryam, Mirnia, Kayvan
• Format: Journal Article
• Language: English
• Published: 01.04.2023
• ISSN: 2008-2142; 2008-2150
• DOI: 10.5812/ijp-129542

Introduction: Ichthyosis is an epidermal disruption that increases insensible water loss. Hypernatremic dehydration is a consequence of skin disruption. This study reviewed the treatment of hypernatremic dehydration in patients with ichthyosis comparing to patients with intact skin. Case Presentation: We studied five neonates with hypernatremia, including three ichthyosis cases and two normal-skin neonates. This case-series study showed that the sodium correction rate is slower in infants with ichthyosis than in infants with normal skin. The first and second neonates needed less sodium than fluid intake than normal skin infants, although fluid requirement was lower in the third ichthyosis infant than in others due to less skin disruption in this infant. Conclusions: Fluid therapy in hypernatremic dehydration in ichthyosis patients is different from neonates with intact skin because of excessive insensible water loss in these patients. It may be needed to give more fluid and less sodium depending on the degree of skin disruption, which may not be determined by physical examination.