A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO − in living cells, image ONOO − in paw edema mi...

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Published inChemical communications (Cambridge, England) Vol. 6; no. 52; pp. 6675 - 6678
Main Authors Hu, Ling, Chen, Si-Si, Zhang, Hui, Chao, Jing-Jing, Peng, Zhen-Zhen, Mao, Guo-Jiang, Hu, Liufang, Ouyang, Juan, Min, Anjie, Li, Chun-Yan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 25.06.2024
Subjects
Edema
Fluorescent indicators
Near infrared radiation
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Summary:A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO − in living cells, image ONOO − in paw edema mice and evaluate anti-inflammatory drugs. A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has long emission and large Stokes shift. TX-P can be used to visualize ONOO − in cells, image ONOO − in paw edema mice and evaluate anti-inflammatory drugs.
Bibliography:Electronic supplementary information (ESI) available: Experimental section, synthesis of the probes and biological assays. See DOI
https://doi.org/10.1039/d4cc01562b
ObjectType-Article-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc01562b