The Experimental Study with the Induction of Cytokines by Methicillin-Resistant Staphylococcus aureus Causative Strains of Postoperative Enterocolitis in Gastroenterological Surgery

• Published in: Nippon Shokaki Geka Gakkai zasshi Vol. 30; no. 7; pp. 1734 - 1738
• Main Authors: Santo, Takahiro, Yokoyama, Takashi, Kodama, Takashi, Takesue, Yoshio, Hiyama, Eizo, Murakami, Yoshiaki, Imamura, Yuji, Shinbara, Kanae, Tsumura, Hiroaki, Matsuura, Yuichiro
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Gastroenterological Surgery 1997
• Subjects: inflamatory cytokines; Methicillin-resistant Staphrlococcus aureus; Methicillin-resistant Staphylococcus aureus enterocolitis; staphylococcal ellterotoxin; toxic shock syndrome toxin-1
• ISSN: 0386-9768; 1348-9372
• DOI: 10.5833/jjgs.30.1734

In order to study the characteristics of the strains causing Methicillin-resistant Staphylococcus aureus (MRSA) enterocolitis, we investigated the coagulase type and the production of staphylococcal enterotoxin (SE) of MRSA strains isolated in our ward for the past 13 years.Among the 28 strains causing MRSA enterocolitis, the first One Was a Coagulase type II and SE C and TSST-1-producing Strain (II CT type), and the remaining 27 strains were coagulase type II and SE C, SE A and TSST-1-producing strains (IIACT type)-Tumor necrosis factorα (TNFα) and interleukin-2 (IL2) production from human peripheral blood mononuclear cell sincubated with the culture supernatant of various types of MRSA was examined.TNFα and IL-2 production from human peripheral blood mononuclear cells incubated with the culture supernatant of the II ACT type of MRSA was the highest.Methylpredonisolone or human immunoglobulin SignifiCantly reduced the TNFαand IL-2 production in the cultures (p<0.05).These results suggest that methylpredonisolone or human immunoglobulin is effective in the treatment of MRSA enterocolitis.