Advancements in electrochemical biosensing of cardiovascular disease biomarkers

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 12; no. 26; pp. 635 - 6327
• Main Authors: Kogularasu, Sakthivel, Lin, Wan-Ching, Lee, Yen-Yi, Huang, Bo-Wun, Chen, Yung-Lung, Chang-Chien, Guo-Ping, Sheu, Jinn-Kong
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 03.07.2024
• Subjects: Biomarkers; Biosensors; Cardiovascular diseases; Electrochemistry; Global health; Microfluidics; Public health; Risk factors; Transducers
• ISSN: 2050-750X; 2050-7518; 2050-7518
• DOI: 10.1039/d4tb00333k

Cardiovascular diseases (CVDs) stand as a predominant global health concern, introducing vast socioeconomic challenges. In addressing this pressing dilemma, enhanced diagnostic modalities have become paramount, positioning electrochemical biosensing as an instrumental innovation. This comprehensive review navigates the multifaceted terrain of CVDs, elucidating their defining characteristics, clinical manifestations, therapeutic avenues, and intrinsic risk factors. Notable emphasis is placed on pivotal diagnostic tools, spotlighting cardiac biomarkers distinguished by their unmatched clinical precision in terms of relevance, sensitivity, and specificity. Highlighting the broader repercussions of CVDs, there emerges an accentuated need for refined diagnostic strategies. Such an exploration segues into a profound analysis of electrochemical biosensing, encapsulating its foundational principles, diverse classifications, and integral components, notably recognition molecules and transducers. Contemporary advancements in biosensing technologies are brought to the fore, emphasizing pioneering electrode architectures, cutting-edge signal amplification processes, and the synergistic integration of biosensors with microfluidic platforms. At the core of this discourse is the demonstrated proficiency of biosensors in detecting cardiovascular anomalies, underpinned by empirical case studies, systematic evaluations, and clinical insights. As the narrative unfolds, it addresses an array of inherent challenges, spanning intricate technicalities, real-world applicability constraints, and regulatory considerations, finally, by casting an anticipatory gaze upon the future of electrochemical biosensing, heralding a new era of diagnostic tools primed to revolutionize cardiovascular healthcare. Cutting-edge electrochemical biosensing techniques for detecting key cardiovascular disease biomarkers utilizing various technologies are explored.