Allopurinol prevents ischaemia-dependent haemorheological changes

Pre-treatment with allopurinol is able markedly to attenuate the deterioration in blood viscosity (BV) and whole blood filterability (WBF) that occurs after ischaemia during exercise. It also reduces the exercise-induced increase in serum oxidase activity, although this action is slightly less effec...

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Published inEuropean journal of clinical pharmacology Vol. 35; no. 5; p. 475
Main Authors Capecchi, P L, Pasini, F L, Pasqui, A L, Orrico, A, Ceccatelli, L, Acciavatti, A, Galigani, C, Pieragalli, D, Di Perri, T
Format Journal Article
LanguageEnglish
Published Germany 01.09.1988
Subjects
Aged
Allopurinol - pharmacology
Arterial Occlusive Diseases - blood
Arterial Occlusive Diseases - drug therapy
Blood Viscosity - drug effects
Coronary Disease - blood
Coronary Disease - drug therapy
Female
Glucuronidase - blood
Humans
In Vitro Techniques
Male
Middle Aged
Neutrophils - drug effects
Neutrophils - metabolism
Physical Exertion
Rheology
Superoxides - blood
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Summary:Pre-treatment with allopurinol is able markedly to attenuate the deterioration in blood viscosity (BV) and whole blood filterability (WBF) that occurs after ischaemia during exercise. It also reduces the exercise-induced increase in serum oxidase activity, although this action is slightly less effective in peripheral obliterative arterial disease (POAD) patients. Conversely, allopurinol is completely ineffective in modifying haemorheological parameters in vitro, and it does not affect superoxide anion generation or enzyme release from neutrophils stimulated in vitro with formyl-methionyl-leucyl-phenylalanine (FMLP). It is suggested that allopurinol may attenuate changes in BV and WBF by affecting xanthine-oxidase-dependent free radical formation in tissues.
ISSN:0031-6970
DOI:10.1007/BF00558241