The relation between pituitary gland and thyroid growth during the lifespan of the annual fish Cynolebias whitei and Nothobranchius korthausae: gonadotropic and thyrotropic cells

• Published in: Cell and tissue research Vol. 248; no. 3; p. 689
• Main Authors: Ruijter, J M, Peute, J, Levels, P J
• Format: Journal Article
• Language: English
• Published: Germany 01.06.1987
• Subjects: Aging; Animals; Cyprinidae - growth & development; Female; Gonadotropins - analysis; Male; Microscopy, Electron; Pituitary Gland - cytology; Pituitary Gland - growth & development; Pituitary Gland - ultrastructure; Species Specificity; Thyroid Gland - cytology; Thyroid Gland - growth & development; Thyrotropin - analysis
• ISSN: 0302-766X
• DOI: 10.1007/BF00216500

In the annual cyprinodont Cynolebias whitei the cell types responsible for the increase of pituitary growth at the onset of maturation and for pituitary hyperplasia in old specimens were identified as gonadotropic cells and thyrotropic cells, respectively. The gonadotropic cells showed a high affinity to anti-carp alpha beta-GTH serum, both at light- and electron-microscopical levels. The allometric relation of total gonadotropic cell volume to body length, determined for fish from six weeks up to six months of age, showed no inflections. Therefore pituitary growth in maturing fish may be partly a result of proliferation of gonadotropes, although gonadotropic cells do not contribute to pituitary hyperplasia in old fish. Thyrotropic cells showed a weak affinity to anti-carp alpha beta-GTH serum at light-microscopical level. Under the electron microscope thyrotropic cells displayed signs of activation in maturing fish and signs of proliferation in old fish. The allometric relation of thyroid gland volume to body length paralleled that of pituitary volume to body length. Histologically the thyroid gland showed signs of inactivity in adult fish and of hyperplasia in old fish. The possibility, that gonadal maturation, pituitary thyrotropic activity, and growth of the thyroid in maturing fish are related through the inhibitory action of gonadal steroids on thyroid hormone release, is discussed. Pituitary hyperplasia in old fish is the result of proliferation of thyrotropic cells. Similar hyperplasia of pituitary and thyroid glands was observed in old Nothobranchius korthausae.