Vaccinal prevention of Tick-Borne Encephalitis in chelyabinsk Region: Dynamics of Vaccination, population Immunity, Analysis of TBE cases in Vaccinated persons

• Published in: Èpidemiologiâ i vakcinoprofilaktika (Online) Vol. 15; no. 1; pp. 67 - 76
• Main Authors: Luchinina, S. V., Semenov, A. I., Stepanova, O. N., Pogodina, V. V., Gerasimov, S. G., Shcherbinina, M. S., Kolesnikova, L. I., Suslova, T. A.
• Format: Journal Article
• Language: English; Russian
• Published: Numikom LLC 20.02.2016
• Subjects: chelyabinsk region; population immunity; southern urals; tbe; vaccination; вакцинальный иммунитет; вакцинопрофилактика; клещевой энцефалит; популяционный иммунитет; сибирский подтип вируса; челябинская область
• ISSN: 2073-3046; 2619-0494
• DOI: 10.31631/2073-3046-2016-15-1-67-76

The Chelyabinsk Region (Southern Urals) is high endemic territory. The TBE incidence is 3.57 ± 1.7 per 100 000 of population. A level of vaccination against TBE increased from 0.3 to 34.8% in 1999 - 2013. Specific immunity of population in 35.9% is connected with vaccination, in 64.1% with natural immunity consequently latent contact with TBE virus. Dynamics of vaccinal prevention, increasing of population immunity in different landscapes, and in different age groups were studied. 77.7% of TBE patients did not vaccinated, 18.2% received of specific immunoglobulin at postexposition and 3.7% persons were vaccinated. Unusual lethal case in patient, who received 8 doses of vaccine is analysed in this article.