MODERN OSTEOARTHRITIS THERAPY: ALFLUTOP IN CLINICAL PRACTICE, EXPERIMENTAL AND CLINICAL DATA

The article discusses experimental data that demonstrated the ability of Aflutop to stimulate proliferation and regeneration of chondrocytes, to inhibate in vitro extracellular release of IL-6 cytokine and IL-8 chemokine compared to control cells, to inhibit VEGF, a proangiogenic factor, a biochemic...

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Bibliographic Details
Published inMedicinskij sovet no. 17; pp. 138 - 145
Main Author N. V. Chichasova
Format Journal Article
LanguageRussian
Published Remedium Group LLC 01.11.2017
Subjects
alflutop
clinical effectiveness
cytokines
metalloproteases
osteoarthritis
oxidative stress
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Summary:The article discusses experimental data that demonstrated the ability of Aflutop to stimulate proliferation and regeneration of chondrocytes, to inhibate in vitro extracellular release of IL-6 cytokine and IL-8 chemokine compared to control cells, to inhibit VEGF, a proangiogenic factor, a biochemical proactive factor in destructive processes of OA, as well as the proven existence of the antioxidant activity of Alflutop. The data of numerous clinical studies (including the double blind placebo-controlled) show that it has an expressed analgesic effect, developing in the first weeks after administration in osteoarthritis patients, including with periarthrites, osteochondrosis, with back pain of different genesis, and the existence of the anti-inflammatory effect and a positive impact on the quality of life of osteoarthritis patients. At a high evidentiary level, the structural modifying effect of Alflutop and its safety is confirmed.
ISSN:2079-701X
2658-5790
DOI:10.21518/2079-701X-2017-17-138-145