Slipping pumps or proton leaks in oxidative phosphorylation

Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.

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Bibliographic Details
Published inFEBS letters Vol. 277; no. 1-2; pp. 131 - 133
Main Authors van Dam, Karel, Shinohara, Yasuo, Unami, Akira, Yoshida, Kenji, Terada, Hiroshi
Format Journal Article
LanguageEnglish
Published 17.12.1990
Subjects
Local anesthetic
Mitochondria
Oxidative phosphorylation
Proton pump
Uncoupling
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Summary:Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80826-5