Casein phosphopeptides improve zinc and calcium absorption from rice-based but not from whole-grain infant cereal

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 24; no. 1; p. 56
• Main Authors: Hansen, M. (Royal Veterinary and Agricultural University, Frederiksberg, Denmark.), Sandstrom, B, Jensen, M, Sorensen, S.S
• Format: Journal Article
• Language: English
• Published: United States 01.01.1997
• Subjects: ABSORCION; ABSORPTION; Adult; ALIMENT POUR NOURRISSON; ALIMENTOS PARA NINOS; ARROZ; Biological Availability; BLE; Calcium - pharmacokinetics; Calcium - urine; Calcium Radioisotopes; Caseins - administration & dosage; Caseins - pharmacology; CEREALE; CEREALES; Female; Humans; Infant; Infant Food; Intestinal Absorption; Male; Oryza; Peptide Fragments - pharmacology; Phosphopeptides - administration & dosage; Phosphopeptides - pharmacology; RIZ; TRIGO; Triticum; Zinc - pharmacokinetics; Zinc Radioisotopes
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1002/j.1536-4801.1997.tb01452.x

Background: Casein phosphopeptides (CPP) are phosphorus-rich peptide fragments of casein, assumed to contribute to the high bioavailability of calcium from milk. Methods: The effect of casein phosphopeptides on calcium and zinc absorption from infant foods was investigated. Twenty-two men and women were given single test meals extrinsically labeled with Ca and Zn. Absorption was calculated from measurements on whole-body retention of the radioisotopes. Each subject was given either rice-based cereal (n = 11) or whole-grain cereal (n = 11) on three occasions together with 250 ml water and added 0, 1, and 2 g CPP in random order. One serving of rice-based cereal contained 481 mg Ca and 1.29 mg Zn; whole-grain cereal contained 541 mg Ca and 1.77 mg Zn. One and 2 g of CPP contributed with additional 69 and 138 mg Ca, respectively. Results: From rice-based cereal, fractional calcium absorption was not affected by CPP addition (mean +/- SD): 16.0 +/- 4.0% (no CPP). 17.6 +/- 4.5% (1 g CPP), and 15.8 +/- 4.3% (2 g CPP), while the total quantity of calcium absorbed was significantly improved: 7 +/- 19 ma, 97 +/- 25 ma, and 98 +/- 26 ma, respectively (p = 0.0004). Fractional zinc absorption as well as total quantity of zinc absorbed were increased with addition of CPP: 19.4 +/- 9.0% (0.25 +/- 0.12 mg), 25.2 +/- 7.5% (0.33 +/- 0.10 ma) and 23.9 +/- 5.4% (0.31 +/- 0.07 ma) at the three CPP levels (p = 0.04). From whole-grain cereal, CPP had no effect on the percentage or actual quantity of calcium absorbed: 17.0 +/- 3.2% (92 +/- 18 mg), 17.2 +/- 4.5% (105 +/- 27 mg), and 15.0 +/- 4.6% (102 +/- 31 mg), respectively. Zinc absorption was also not influenced by CPP: 16.0 +/- 5.1% (0.28 +/- 0.09 mg), 15.3 +/- 3.1% (0.27 +/- 0.06 ma) and 18.1 +/- 4.4% (0.32 +/- 0.08 mg), respectively. Conclusions: CPP addition improved calcium and zinc absorption from rice-based cereal, while no effect was seen from whole-grain cereal