Familial non-rcd 1 generalised retinal degeneration in Irish setters

Four Irish setters were diagnosed with bilateral retinal degeneration and cataracts at an age ranging from six to 11 years. In three of these dogs, progressive night blindness was reported from an age of eight to 11 years. In the fourth dog, aged six, no signs of visual impairment had been noticed....

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Bibliographic Details
Published inJournal of small animal practice Vol. 44; no. 3; pp. 113 - 116
Main Authors Djajadiningrat-Laanen, S.C, Boeve, M.H, Stades, F.C, Oost, B.A. van
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2003
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Summary:Four Irish setters were diagnosed with bilateral retinal degeneration and cataracts at an age ranging from six to 11 years. In three of these dogs, progressive night blindness was reported from an age of eight to 11 years. In the fourth dog, aged six, no signs of visual impairment had been noticed. In all four dogs, the rod-cone dysplasia type 1 (rcd1) mutation was excluded as a cause, using an allele-specific PCR. From their three-generation pedigrees, a familial relationship was detected in three out of four dogs, which were also related to four additional Irish setter dogs with a history and clinical signs suggestive of late-onset progressive retinal degeneration. These results suggest the existence of a possibly hereditary, late-onset, progressive retinal atrophy in the Irish setter breed, that is distinct from rcd1.
Bibliography:istex:970611D51375CBCEE529212528BE093FA7CC8341
ark:/67375/WNG-G6PNWR1K-F
ArticleID:JSAP113
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.2003.tb00130.x