Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis

• Published in: Uchenye zapiski (Sankt-Peterburgskiĭ gosudarstvennyĭ medit͡s︡inskiĭ universitet im. akad. I.P. Pavlova) Vol. 23; no. 2; pp. 15 - 20
• Main Authors: Ionova, Z. I., Sergeeva, E. G., Berkovich, O. A., Pchelina, S. N., Baranova, E. I.
• Format: Journal Article
• Language: English; Russian
• Published: Academician I.P. Pavlov First St. Petersburg State Medical University 01.06.2016
• Subjects: ppar; алеглитазар; омега-3 пнжк; рецепторы активатора пролиферации пероксисом; статины; тиазолидиндионы; фибраты
• ISSN: 1607-4181; 2541-8807
• DOI: 10.24884/1607-4181-2016-23-2-15-20

Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis.