CLINICAL PROFILE OF DENGUE HAEMORRHAGIC FEVER FROM JAN 2009 TO DEC 2009 IN AND AROUND AURANGABAD

• Published in: Journal of evolution of medical and dental sciences Vol. 2; no. 48; pp. 9426 - 9429
• Main Authors: Mangala M., Duthade, Bhakare, Jayshree B, Damle, A.S
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 02.12.2013
• Subjects: Dengue hemorrhagic fever; Distribution; Forecasts and trends; Physiological aspects; India
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/1634

In present study 890 serum samples of patients suspected of dengue fever on clinical grounds were received in department of Microbiology. Out of these 249 cases showed thrombocytopenia (platelet count <1 lakh/cumm) and were subjected to rapid dengue serological test as well as IgM capture ELISA. 11/ 249 (4%) cases were diagnosed as primary dengue infection (only IgM positive) by rapid dengue IgG/IgM bispot immunocomb test. There were 123(49%) cases with only IgG positive suggesting secondary/past dengue infection. Both IgM and IgG were positive in 24(10%) cases. Number of cases negative for both IgM and IgG were 91(37%). IgM positive cases were confirmed by IgM capture ELISA. Classical dengue fever (DF) was noted in 168 (67%) patients and dengue hemorrhagic fever (DHF) in 81(33%) cases. Common clinical presentations of DHF were fever 78(96%), body-ache 74(91%), arthralgia 74 (91%), retro-orbital pain 65(80%), abdominal pain 07(09%). Bleeding manifestation were in the form of petechiae, melena, epistaxis, hematuria, hemoptysis, hematemesis, bleeding gums and conjunctival hemorrhages. Out of 81 Dengue haemorrhagic fever (DHF) patients 13(16%) patients had platelet count between 50,000 and 1 lakh. 68(84%) patients had platelet count below 50,000. Majority of these patients 47(58%) had platelet below 20000 and were IgG positive. Thrombocytopenia correlated well with bleeding manifestations in our patients. In an epidemic setting if the patients present with fever, vomiting, musculoskeletal pain and bleeding along with low platelet count a strong possibility of DHF/ Dengue shock syndrome (DSS) should be kept in mind.