The use of hydrazones for efficient mannich type coupling with aldehydes and secondary amines

The Mannich reaction of hydrazones originally limited to the coupling of hydrazones with formaldehyde has been extended to a large variety of aldehydes through appropriate selection of experimental conditions; in conjunction with the Japp-Klingmann reaction, this process provides an efficient synthe...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 17; pp. 1585 - 1586
Main Authors Atlan, Bienayme, H, El Kaim, L, Majee, A
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2000
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:The Mannich reaction of hydrazones originally limited to the coupling of hydrazones with formaldehyde has been extended to a large variety of aldehydes through appropriate selection of experimental conditions; in conjunction with the Japp-Klingmann reaction, this process provides an efficient synthetic tool for the formation of carbon-carbon bonds.
ISSN:1359-7345
1364-548X
DOI:10.1039/b002750m